[S-17] Mechanisms of novel pathogenic autoantibodies in chronic immune-mediated neuropathies

[S-17-4] Anti-plexinD1 antibody and painful neuropathy

Takayuki Fujii, Ryo Yamasaki, Jun-ichi Kira (Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan)

Newly discovered autoantibodies that react with the specific sites of peripheral nerves produces unique clinical manifestations and laboratory findings, such as neuropathic pain, autonomic symptoms, nerve hypertrophy, and axo-glial detachment. These manifestations might be originated from antibody-antigen interaction at specific sites such as nodes of Ranvier, paranodes, posterior ganglion small neurons, and autonomic ganglia. This symposium encompasses anti-neurofascin155 and -contactin1 antibodies targeting the paranodes, anti-plexinD1 antibody targeting the primary pain-conducting neurons, and anti-ganglionic acetylcholine receptor antibody targeting the autonomic ganglia. These autoantibodies could be not only diagnostic biomarkers but also pathogenic. The purpose of this symposium is to deepen the knowledge about the mechanism and cascade of events leading to the specific manifestations of neuropathy by each autoantibody.

Education:
2019 Doctorate of Medical Science, Department of Neurology, Kyushu University
Kyushu University, Fukuoka, Japan

Work Experience:
April 2009-Mar 2011, Fukuoka City Hospital, Junior Resident
April 2011-January 2012, Department of Neurology, Kyushu University Hospital, Medical staff
February 2012-March 2012, Department of Neurology, National Hospital Organization Omuta Hospital, Medical Staff
April 2012-March 2014, Department of Neurology, Kokura Memorial Hospital, Medical staff
April 2014-March 2018, Department of Neurology, Kyushu University Hospital, Medical staff
April 2018-Present, Department of Neurology, Kyushu University Hospital, Clinical assistant professor

Licenses:
Fellow of the Japanese Society of Internal Medicine
Fellow of the Japanese Society of Neurology