[S-24] Potential disease modifying therapies for Parkinson disease

[S-24-1] Therapies for PD via modifying actions of extracellular alpha-synuclein

Seung-Jae Lee (Department of Biomedical Sciences, Seoul National University College of Medicine)

The concept of “disease modification” encompasses intervention types ranging from those designed to slow the underlying degeneration to treatments aiming at compensating lost neuronal functions. It is the ultimate goal of Parkinson disease treatment, although all attempts to develop effective disease-modifying therapy have failed to date. Many reasons have been proposed for these failures including our poor understanding of disease pathogenesis and the lack of sensitive surrogate markers of PD. Moreover, several observations suggest that the PD is not a single disease, but syndrome based on a variety of pathophysiological mechanisms. However, recently several promising new approaches have been reported and attracted attentions. The aim of this symposium is to elucidate true possibilities and real limitations of such novel trials.

POSITIONS:
2015- Professor, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

2011-2015 Professor, Department of Biomedical Science and Technology, Konkuk University, Seoul, Korea

2006-2011 Associate Professor, Department of Biomedical Science and Technology, Konkuk University, Seoul, Korea

2000-2006 Assistant Professor, The Parkinson’s Institute, Sunnyvale, CA

1998-2000 Instructor in Neurology, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA

1996-1998 Postdoctoral Fellow, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA

1995-1996 Postdoctoral Fellow, Laboratory of Molecular Cardiology, NHLBI, NIH, Bethesda, MD

EDUCATION:
1992-1995 PhD Department of Life Science, Pohang University of Science and Technology, Pohang, Korea

1990-1992 M.S. Department of Life Science, Pohang University of Science and Technology, Pohang, Korea

1985-1989 B.S. Department of Biology Education, Seoul National University, Seoul, Korea

AWARDS AND HONORS:
1995-1997 NIH Postdoctoral Fellowship from Fogarty International Center
2000 International Parkinson’s Research Award (Parkinson’s disease foundation)
2010, 2014 Excellence in Basic Research (Ministry of Education, Science, and Technology)
2012, 2014 Excellent paper award in science and technology (The Korean Federation of Science and Technology Societies)
2013 Research Grand Prize, Konkuk University
2016 Research Excellence Award, Seoul National University College of Medicine

EDITORIAL
2010- Experimental Neurobiology (Associate Editor)
2011- Journal of Parkinson’s disease
2016- Brain Research (Senior Editor)
2017- Experimental Molecular Medicine (Associate Editor)