[S-35] Progressive multifocal leukoencephalopathy in the era of disease-modifying therapies

[S-35-3] Characteristics of MR imaging on progressive multifocal leukoencephalopathy and recent advance

Masafumi Harada, Takashi Abe, Yuko Sakamoto (Department of Radiology, Tokushima University, Japan)

Progressive multifocal leukoencephalopathy (PML) is a rare and severe demyelinating disease of the white matter in the central nervous system caused by JC virus. Multiple sclerosis (MS) treating with disease-modifying therapies (DMT) is newly coming underlying disease of PML. In MS, DMT have recently been shown to reduce the frequency and severity of clinical relapse. Although freedom from disease activity has become the primary aim of the treatment of MS, these DMT increase the risk of PML.
In this symposium, latest information of DMT induced PML, characteristics of MRI in DMT induced PML, development of JC virus DNA detection in the cerebrospinal fluid, and newly aspects of PML will be presented.

1980-1986 School of Medicine, Tokushima University, BSc and Medical license
1986-1990 Graduate School of Medicine, Tokushima University, Ph.D. in Radiology
1991 Board certification of Radiology,

1990-1992 Research Associate, Department of Radiology, School of Medicine, University of Tokushima
1992-1993 Department of Biochemistry and Biophysics, University of Pennsilvania
1993-1996 Assistant Professor, Department of Radiology, Tokushima University
1996-1997 Center for Magnetic Resonance Research, University of Minnesota
1998-2001 Associate Professor, Department of Radiology, Tokushima University
2002-2010 Professor, Department of Medical Imaging, Institute of Health Biosciences, Tokushima University
2010-present Chair and Professor, Department of Radiology, Tokushima University
2013-present Specially-appointed professor, Fukushima Medical University
2013-present President of TDI Network Organization
2016-2018 President of Japan Society of Magnetic Resonance in Medicine