[NFS-02] Neuroscience Frontier Symposium 02
日本から世界へ発信する、SCA新規病態の解明と治療薬の開発

[NFS-02-1] 脊髄小脳失調症３１型（SCA31)の分子病態

^○石川 欽也¹, 東 美和², 大北 倫¹, 青木 華古², 淺香 明子³, 石黒 太郎², 佐藤 望², 永井 義隆⁴, 柳原 大³, 横田 隆徳² (1.東京医科歯科大学病院 長寿・健康人生推進センター, 2.東京医科歯科大学大学院脳神経病態学分野, 3.東京大学大学院総合文化研究科, 4.大阪大学大学院医学系研究科 神経難病認知症探索治療学寄附講座)

Spinocerebellar ataxia (SCA) is neurodegenerative diseases affecting mainly cerebellum and brainstem, and new subtypes and pathologies of SCAs have been continuously discovered in the world. Especially, SCA31 and SCA36 (nicknamed Asidan) were first found in Japanese, and their clinical and pathological features are quite unique compared with other SCAs. Recent discovery of repeat associated non-ATG (RAN) translation in the pathogenesis of hereditary SCAs carrying repeat expansion mutations has tremendously extended our understanding in the pathogenesis of SCA and other neurodegenerative diseases. Furthermore, the development of new therapy for SCAs have been extensively investigated in Japan and the world. The aim of this symposium is to learn and discuss the current clinical, pathological and therapeutic findings of SCAs for Japanese and Asian neurologists and neuroscientists.

1989 Graduated from the University of Tsukuba, Medical School.
1999 Assistant Professor, Department of Neurology, Tokyo Medical and Dental University
(Professor Hidehiro Mizusawa)
2003 Junior Associate Professor, Department of Neurology, Tokyo Medical and Dental University
2015 Professor, Center for Personalized Medicine for Healthy Aging, Tokyo Medical and Dental University