[S-16-4] Clinical variability of autoimmune epilepsy
The epilepsy syndrome of autoimmune etiology, namely, autoimmune epilepsy has attracted attention in recent years. Neural-specific autoantibodies such as anti-NMDA-R and LGI1 antibodies were found, which cause autoimmune epilepsy. Seronegative patients are also existed, and a diagnostic algorithm is required for the diagnosis. Immune therapy should be started in the acute phase as soon as possible in addition to antiepileptic therapy. Especially, new-onset refractory status epilepticus (NORSE) is one of the most challenging status in terms of treatment of acute phase. On the other hand, the presence of smoldering type should be noted with clinical variabilities of autoimmune epilepsy. In this session, pathophysiology, proposal for diagnostic algorithm, management of acute phase, and clinical variabilities of autoimmune epilepsies will be presented by experts in this field.
EDUCATION AND TRAINING:
1996: M.D., Tohoku University School of Medicine, Sendai, Japan
1996-1998: Resident (Neurology), Tohoku University Hospital
2007: Ph.D., Tohoku University Graduate School of Medicine
RESEARCH AND PROFESSIONAL EXPERIENCE:
2003-2007: Visiting Researcher, MEG Laboratory, Kohnan Hospital, Sendai, Japan
2006-2007: Assistant Professor, Department of Neurology, Tohoku University Graduate School of Medicine
2007-2010: Research fellow, Epilepsy center, Cleveland Clinic, Ohio, USA
2010-2011: Assistant Professor, Department of Epileptology, Tohoku University Graduate School of Medicine
2011-present: Current position
LICENSE AND BOARD CERTIFICATIONS:
Board Certification, Japanese Society of Neurology, 2000
Board Certification, Japan Epilepsy Society, 2011
Board Certification, Japanese Society of Clinical Neurophysiology, 2012
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