[S-36] Symposium 36
Development of new frontier for elucidation of multiple system atrophy

[S-36-1] Cellular pathology in multiple system atrophy

^○Koichi Wakabayashi (Department of Neuropathology, Hirosaki University Graduate School of Medicine, Japan)

Multisystem atrophy (MSA) is a multi-system neurodegenerative disease of the cerebellum, pyramidal and extrapyramidal tract, and autonomic nervous system, which is characterized by the α-synuclein deposition in oligodendrocytes. There are still many unsolved issues about the pathological mechanism, and there is an urgent need to develop new therapeutic agents. Researches on MSA mainly cover the pathogenesis of α-synuclein, and includes disease-causing factors in DNA polymorphisms and microRNAs, and the dysfunction of neural networks by fMRI. It is important to confirm and discuss about the latest knowledge to develop further researches on MSA. Therefore, in this symposium, the latest research results on MSA in Japan will be presented, aiming discussion between speakers and participants to establish a new research goal on MSA.

Education:
Toyama Medical and Pharmaceutical University 1978-1985 (M.D. 1985)
Niigata University Graduate School of Medicine 1985-1989 (Ph.D. 1989)

Positions Held:
1989-1991 Research Fellow, Brain Research Institute, Niigata University
1991-1996 Assistant Professor, Brain Research Institute, Niigata University
1993-1994 Research Fellow, Department of Neurosciences, University of California at San Diego
1996-2000 Associate Professor, Brain Research Institute, Niigata University
2000-present Professor, Department of Neuropathology, Hirosaki University Graduate School of Medicine

Awards:
Japanese Society of Neurology Narabayashi Award 2016