[S-36-2] 多系統萎縮症における大脳-小脳間の安静時機能的ネットワーク障害
Multisystem atrophy (MSA) is a multi-system neurodegenerative disease of the cerebellum, pyramidal and extrapyramidal tract, and autonomic nervous system, which is characterized by the α-synuclein deposition in oligodendrocytes. There are still many unsolved issues about the pathological mechanism, and there is an urgent need to develop new therapeutic agents. Researches on MSA mainly cover the pathogenesis of α-synuclein, and includes disease-causing factors in DNA polymorphisms and microRNAs, and the dysfunction of neural networks by fMRI. It is important to confirm and discuss about the latest knowledge to develop further researches on MSA. Therefore, in this symposium, the latest research results on MSA in Japan will be presented, aiming discussion between speakers and participants to establish a new research goal on MSA.
Dr. Hirohisa Watanabe is currently a Professor and Chairperson of the Department of Neurology, Fujita Health University school of medicine. He graduated from Mie University School of Medicine in 1993, received his neurological training at Nagoya Daini Red Cross Hospital and Nagoya University Hospital, and was certified as a neurologist by the Japanese Society of Neurology. He intensively investigated the relationship between brain network changes and aging as well as neurodegenerative diseases in Brain and Mind Research Center, Nagoya University as a designated professor. He is currently a Delegate of the Japanese Society of Neurology, Executive committee member of the Movement Disorders Society Asia & Oceanian Section, Delegate of the Japan Society of Neurovegetative Research, Delegate of the Japanese Society for Dementia Research, and Delegate of the Japanese Society of Neurological Therapeutics.
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