[SL] 特別講演
Roles of intrinsically disordered proteins in neuronal heath and disease

[SL-1] Roles of intrinsically disordered proteins in neuronal heath and disease

^○Peter St. George-Hyslop¹, Ryuta Morihara^2,3, Tetsuro Murakami², Seema Qamar¹, Tuomas Knowles¹, Michele Vendruscolo¹ (1.University of Cambridge, 2.University of Toronto, 3.Okayama University)

Professor Peter St George-Hyslop, OC, MD, FRCP(C), FMedSci, FRS
Professor St George-Hyslop has made major contributions to the understanding of the functional genomics of multiple human neurodegenerative diseases including Alzheimer disease, frontotemporal dementia and ALS. He has played a major role in cloning of genes associated with susceptibility to these disorders including APP, APOE, PS1, PS2, SORL1, TREM2 and several others. He has built protein structural, molecular, cellular and animal models of these disorders, and used them to explore candidate therapeutics including early work on anti-Abeta vaccines, inhibitors of Abeta aggregation, and inhibitors of gamma-secretase, and microglial modulators such as CSF1R inhibitors. He is currently University Professor in the Division of Neurology, Department of Medicine at The University of Toronto, and Professor of Experimental Neuroscience at the University of Cambridge. He has received numerous academic honours including election to the Royal Society of London, Royal Society of Canada, US National Academy of Medicine, the Order of Canada and the UK Academy of Medical Sciences, as well as the Howard Hughes International Scholar Award, Potamkin prize, Metropolitan Life Award, Dan David Prize, Ryman Prize, Zenith Award and Royal College of Physicians of Canada Gold Medal in Medicine.