Neuroscience Frontier Symposium
Thu. May 20, 2021 4:15 PM - 6:15 PM Room 05 (ICC Kyoto 2F Room B-1)
Chair：Matsukawa Noriyuki(Department of Neurology, Nagoya City University),Sakai Kenji(Department of Neurology, Kanazawa University Hospital)
The APOE4 is the highest genetic risk factor for sporadic Alzheimer's disease. The frequency of the APOE4 allele is high in the general population. Thus, there is a significant impact on Alzheimer's disease. Elucidating the role of APOE4 in the pathogenesis of Alzheimer's disease would be important. It may also lead to the treatment of Alzheimer's disease that does not associate with APOE4. However, the involvement of APOE4 in the pathogenesis of the Alzheimer's disease has long been shrouded in mystery. Nearly 30 years after its discovery, new aspects for APOE4 participation in Alzheimer's disease's pathogenesis have recently come to light. In this symposium, we will present the remarkable recent advances in the involvement of APOE4 in the pathogenesis of Alzheimer's disease, and we hope to give the audience a sense of the trends in this area of research.
○Yoshinori Nishimoto (Department of Neurology, Keio University, School of Medicine, Japan)
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○Yorito Hattori (Department of Neurology, National Cerebral and Cardiovascular Center, Japan)
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○Yu Yamazaki (Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan)
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○Yuto Uchida1,2, Noriyuki Matsukawa1 (1.Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Japan, 2.Department of Neurology, Toyokawa City Hospital, Japan)
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