Oral Session

[O-05] Oral Session 05 Neuroscience1

Wed. May 19, 2021 4:30 PM - 6:00 PM Room 08 (ICC Kyoto 1F Room E)

Chair：Miyamoto Katsuichi(Department of Neurology, Kindai Univercity School of Medicine),Matsushita Takuya(Department of Neurology, Kyushu University Hospital)

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[O-05-1] ATP induces neuropathic pain in neuromyelitis optica spectrum disorder through microglial activation

^○Teruyuki Ishikura¹, Makoto Kinoshita¹, Mikito Shimizu¹, Yoshiaki Yasumizu¹, Kazuya Yamashita¹, Hisashi Murata¹, Shohei Beppu¹, Toru Koda¹, Satoru Tada¹, Naoyuki Shiraishi¹, Yasuko Sugiyama¹, Katsuichi Miyamoto², Susumu Kusunoki², Atsushi Kumanogoh³, Tatsusada Okuno¹, Hideki Mochizuki¹ (1.Department of Neurology, Osaka University Graduate School of Medicine, Japan, 2.Department of Neurology, Kindai University Faculty of Medicine, Japan, 3.Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Japan)

[O-05-2] IL-6 blockade inhibited the NMO-IgG-induced BBB dysfunction, leading to prevention of onset of NMOSD

^○Yukio Takeshita¹, Susumu Fujikawa¹, Kenichi Serizawa², Miwako Fujisawa¹, Kinya Matsuo¹, Fumitaka Shimizu¹, Yasuteru Sano¹, Michiaki Koga¹, Richard M Ransohoff³, Takashi Kanda¹ (1.Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan, 2.Product Research Department, Chugai Pharmaceutical Co., Ltd, 3.Third Rock Ventures)

[O-05-3] Effects of sera in NMO, MOG, and MS on IgG translocation to central nervous system

^○Miwako Fujisawa, Yukio Takeshita, Susumu Fujikawa, Kinya Matsuo, Fumitaka Shimizu, Yasuteru Sano, Michiaki Koga, Takashi Kanda (Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan)

[O-05-4] Intracerebral transferability of satralizumab in NMO using a new multi-cultured in vitro BBB model

^○Kinya Matsuo¹, Yukio Takeshita¹, Susumu Hujikawa¹, Miwako Hujisawa¹, Kenichi Serizawa², Humitaka Shimizu¹, Yasuteru Sano¹, Michiaki Koga¹, Takashi Kanda¹ (1.Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan, 2.Product Research Department, Chugai Pharmaceutical Co., Ltd)

[O-05-5] Mechanism of neurodegeneration in TTR E61K amyloid neuropathy: electron microscopic study

^○Tatsufumi Murakami¹, Mineykuki Mizuguchi², Kazunori Sango³, Shigenobu Tone⁴, Kazuhiko Watabe⁵, Yoshihide Sunada¹ (1.Department of Neurology, Kawasaki Medical School, Japan, 2.Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 3.Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, 4.School of Science and Engineering, Tokyo Denki University, 5.Department of Medical Technology, Faculty of Health Science, Kyorin University)

[O-05-6] Neuroprotective Crosstalk between Neurotrophic and Innate Immune Receptors induced by an Analgesic

^○Tatsuro Mutoh¹, Yu Fukuda^1,2 (1.Dept. of Neurology and Neuroscience, Fujita Health University Hospital, Japan, 2.Nippon Zoki Pharmaceutical Co., Ltd.)