Oral Session

[O-34] Oral Session 34 Neurogenetics and Gene therapy

Fri. May 21, 2021 9:45 AM - 11:15 AM Room 11 (ICC Kyoto 1F Room 157)

Chair：Hara Hajime(Wellcare Hara Neurological clinic),Saigoh Kazumasa(Kindai University Hospital, Department of Clinical genetics)

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[O-34-1] Trans-ethnic fine-mapping of the major histocompatibility complex region in Parkinson's disease

^○Tatsuhiko Naito^1,2, Wataru Satake¹, Kotaro Ogawa², Ken Suzuki², Jun Hitara^2,3, Yukinori Okada^2,4, Tatsuhi Toda¹ (1.Department of Neurology, The University of Tokyo, Japan, 2.Department of Statistical Genetics, Osaka University, Japan, 3.Pharmaceutical Discovery Research Laboratories, Teijin Pharma Limited, 4.Laboratory of Statistical Immunology, WPI-IFReC, Osaka University)

[O-34-2] Practical approach to the genetic diagnosis of unsolved dystrophinopathies: a stepwise strategy

^○Zhiying Xie¹, Chengyue Sun¹, Meng Yu¹, Yiming Zheng¹, Lingchao Meng¹, Gao Wang², Diana M.. Cornejo-sanchez², Thashi Bharadwaj², Nicolas Pineda-trujillo³, Wei Zhang¹, Suzanne M.. Leal², Isabelle Schrauwen², Zhaoxia Wang¹, Yun Yuan¹ (1.Department of Neurology, Peking University First Hospital, China, 2.Center for Statistical Genetics, Columbia University Medical Center, 3.Departamento de Pediatría, Facultad de Medicina, Universidad de Antioquia)

[O-34-3] Hetereoduplex oligonucleotiede mitigates various types of acute CNS toxicities via CSF route

^○Chunyan Jia, Kotaro Yoshioka, Su Su Lei Mon, Maho Katsuyama, Kie Tanaka-yoshida, Tetsuya Nagata, Takanori Yokota (Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan)

[O-34-4] Therapeutic effects of an optimized myostatin inhibitory peptide

^○Yoshihide Sunada¹, Shunichi Shirakawa¹, Shin-ichiro Nishimatsu², Yutaka Ohsawa¹ (1.Neurology, Kawasaki Medical School, Japan, 2.Natural Science, Kawasaki Medical School)

[O-34-5] A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with ALS

^○Ryoichi Nakamura¹, Kazuharu Misawa^2,3, Genki Tohnai¹, Masahiro Nakatochi¹, Naoki Atsuta¹, Naoki Hayashi¹, Masahisa Katsuno¹, Yuishin Izumi⁴, Nobutaka Hattori⁵, Mitsuya Morita⁶, Akira Taniguchi⁷, Osamu Kano⁸, Masaya Oda⁹, Satoshi Kuwabara¹⁰, Ryuji Kaji⁴, Yukihide Momozawa¹¹, Masao Nagasaki^2,12, Gen Sobue¹, the Japanese Consortium for Amyotrophic Lateral Sclerosis research^1,4,5,6,7 (1.Nagoya University, Japan, 2.Tohoku Medical Megabank Organization, Tohoku University, 3.Kansai Medical University, 4.Tokushima University, 5.Juntendo University, 6.Jichi Medical University, 7.Mie University, 8.Toho University Omori Medical Center, 9.Vihara Hananosato Hospital, 10.Chiba University, 11.RIKEN Center for Integrative Medical Sciences, 12.Kyoto University)

[O-34-6] Restoration of dystrophin ameliorates impaired social behavior and amygdala synapses in mdx52 mice

^○Yasumasa Hashimoto¹, Hiroshi Kuniishi^2,3, Masayuki Sekiguchi², Yoshitsugu Aoki¹ (1.Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Japan, 2.Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, 3.Department of Neuropsychopharmacology, National Institute of Mental Health, NCNP)