2021年5月21日(金) 14:40 〜 16:40 第6会場 (国立京都国際会館 2F Room B-2)

座長：朝比奈 正人(脳神経内科津田沼),小澤 鉄太郎(新潟大学地域医療教育センター魚沼基幹病院神経内科)

Autonomic dysfunction is the characteristic clinical symptom in patients with multiple system atrophy (MSA). The lesions responsible for autonomic dysfunction in MSA achieve widespread distribution in the central nervous system. The leading hypothesis on the pathogenesis of MSA is that there is propagation of the alpha-synuclein pathology in a prion-like fashion in the vulnerable regions in the central nervous system. The autonomic nervous system is considered to be a potential candidate for alpha-synuclein transmission in MSA brains. To determine the pathogenesis of MSA, it is crucial that detailed investigations of the autonomic dysfunction aspects should be undertaken. The aim of this proposed symposium would be to update the information on the autonomic neuroscience leading to a better understanding of the pathogenic mechanism and progression of MSA disease.