NEURO62

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Symposium

[S-34] Symposium 34 Increasing importance of autonomic neuroscience in multiple system atrophy

Fri. May 21, 2021 2:40 PM - 4:40 PM Room 06 (ICC Kyoto 2F Room B-2)

Chair：Asahina Masato(Neurology Clinic Tsudanuma),Ozawa Tetsutaro(Department of Neurology, Uonuma Institute of Community Medicine, Niigata University)

Autonomic dysfunction is the characteristic clinical symptom in patients with multiple system atrophy (MSA). The lesions responsible for autonomic dysfunction in MSA achieve widespread distribution in the central nervous system. The leading hypothesis on the pathogenesis of MSA is that there is propagation of the alpha-synuclein pathology in a prion-like fashion in the vulnerable regions in the central nervous system. The autonomic nervous system is considered to be a potential candidate for alpha-synuclein transmission in MSA brains. To determine the pathogenesis of MSA, it is crucial that detailed investigations of the autonomic dysfunction aspects should be undertaken. The aim of this proposed symposium would be to update the information on the autonomic neuroscience leading to a better understanding of the pathogenic mechanism and progression of MSA disease.

[S-34-2] Challenges in the diagnosis of non-motor MSA

○Yasuaki Mizutani1, Ryunosuke Nagao1, Sayuri Shima1, Akihiro Ueda1, Mizuki Ito1, Yuichi Riku2, Mari Yoshida2, Tatsuro Mutoh3, Takashi Ichihara4, Hiroshi Toyama4, Hirohisa Watanabe1 (1.Department of Neurology, Fujita Health University School of Medicine, Japan, 2.Institute for Medical Science of Aging, Aichi Medical University, 3.Fujita Health University Central Japan International Airport Clinic, 4.Department of Radiology, Fujita Health University School of Medicine)