[S-02-1] A Slipped-CAG DNA-Ligand Induces Trinucleotide-Repeat Contractions In Vivo: Mechanism of Action
Christopher E. Pearson, Ph.D.
The Hospital for Sick Children, Genetics & Genome Biology;
Full-Professor, University of Toronto, Molecular Genetics,
Canada Research Chair in Disease-Associated Genome Instability
Toronto, Canada
Ph.D. McGill University. Post-doc in Texas Medical Center (USA) to elucidate mechanisms of disease-causing DNA repeat expansions in myotonic dystrophy, spinocerebellar ataxia, Huntington’s disease, fragile X mental retardation, and amyotrophic lateral sclerosis. Appointed at The Hospital for Sick Children and University of Toronto (1998). Awards: Scholar of Medical Research Council of Canada, Scholar of Canadian Genetic Disease Network, Premier’s Research Excellence Award, International Opportunities Award, Canadian Institutes of Health Research. Currently, Canada Research Chair in Disease-Associated Genome Instability. Member of International Myotonic Dystrophy Consortium. Scientific advisor for the National Fragile X Foundation USA, National Ataxia Foundation USA, Hereditary Disease Foundation, Canadian Neuromuscular Disease Registry, ALS Canada, BioMarin-Prosensa Therapeutics, GlaxoSmithKline, Marigold Foundation, TREAT-NMD, Fragile X Research Foundation Canada, Chaired Awards Committee for American Society of Human Genetics. Co-organized International Conference on Unstable Microsatellites & Human Disease (nine iterations), Associate Editor for PLoSGenetics, Journal Medical Genetics, and Human Genetics. Focus: elucidate mechanisms of somatic disease-causing repeat instability associated with neurological, neurodegenerative and neuromuscular disease, with the goal of developing effective treatments.
My PubMed:
https://www-ncbi-nlm-nih-gov.myaccess.library.utoronto.ca/myncbi/1b9vt-uQxdz5L/bibliography/public/
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