[1O05a1] Social Behavior 1

[1O05a1-03] Increase of kynurenic acid associated with decrease of microglia-derived kynurenine-3-monooxygenase is
involved in depressive-like behavior and dysregulation of
hypothalamic-pituitary-adrenal axis induced
by the chronic unpredictable mild stress

*Masaya Hasegawa¹, Akihiro Mouri^1,4, Kazuo Kunisawa¹, Hisayoshi Kubota¹, Hitomi Kurahashi¹, Aika Kosuge¹, Yasuko Yamamoto², Kuniaki Saito^2,3,4, Toshitaka Nabeshima^3,4 (1. Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2. Dept. Disease Control & Prevention., Grad. Sch. Health Sci., Fujita Health Univ., 3. Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ, 4. NPO.J-DO.)

Keywords:Depression, Hypothalamic-pituitary-adrenal axis , Microglia-derived kynurenine-3-monooxygenase, α7 nicotinic acetylcholine receptor