[1P] F. Disorders of the Nervous System 2

[1P-139] Presenilin is essential for ApoE secretion, a novel role of presenilin involved in Alzheimer's disease pathogenesis

*Kun Zou¹, Sadequl Islam¹, Yang Sun¹, Yuan Gao¹, Tomohisa Nakamura¹, Noriyuki Kimura², Etsuro Matsubara², Kensaku Kasuga³, Takeshi Ikeuchi³, Taisuke Tomita⁴, Makoto Michikawa¹ (1. Dept Biochem, Grad Sch Med, Nagoya City Univ, Nagoya, Japan, 2. Dept Neurol, Sch Med, Oita Univ, Oita, Japan, 3. Dept Mol Genet, Brain Res Inst, Niigata Univ, Niigata, Japan, 4. Dept Neuropathol Neurosci, Faculty Pharm Sci, Univ of Tokyo, Tokyo, Japan)

Keywords:Alzheimer's disease, Presenilin, ApoE, Secretion