[1P] F. Disorders of the Nervous System 2

[1P-145] Failure of DNA Double-Strand Break Repair by Tau Mediates AD Pathology in vitro

*Megumi utsugi Asada^2,1, Kengo Uemura⁶, Takashi Ayaki³, Maiko Uemura⁵, Sumio minamiyama^3,7, Ryota Hikiami^3,7, Toshifumi Morimura⁸, Akemi Shodai⁷, Ryosuke Takahashi³, Takatoshi Ueki⁴, Ayae Kinoshita², Makoto Urushitani^1,7 (1. Molec Neuro Research Center, Grad Sch Med, Univ of Shiga, Otsu, Japan, 2. Dept Human Health Sci, Grad. Sch, Grad Sch Med, Univ of Kyoto, Japan, 3. Dept Neuro, Grad Sch Med, Univ of Kyoto, Japan, 4. Dept of Integrative Anatomy, Grad Sch Med,Univ of Nagoya City, Nagoya, Japan, 5. Center Neurodegenerative Disease Research, Perelman Sch Med, Univ of Pennsylvania, Philadelphia, PA, USA, 6. Ishiki hospital, kagoshima, Japan, 7. Dept Neuro, Grad Sch Med, Univ of Shiga, Otsu, Japan, 8. Research Center for Animal Life Science, Grad Sch Med, Univ of Shiga, Otsu, Japan)

Keywords:Tau, DNA double-strand break, microtubule, Alzheimer’s disease