[1P] F. Disorders of the Nervous System 2

[1P-168] Soluble high-molecular-weight Aβ species inducing cerebral β-amyloidosis are abundant in Alzheimer brains with prominent cerebral amyloid angiopathy.

*Hirokazu Uchigami^1,2, Mayu Kashiwagi-Hakozaki¹, Tomoyasu Matsubara³, Shigeo Murayama^3,4, Yuko Saito³, Tatsushi Toda², Tadafumi Hashimoto^1,5, Takeshi Iwatsubo¹ (1. Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 2. Department of Neurology, Graduate School of Medicine, The University of Tokyo, 3. Department of Neurology and Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 4. Brain Bank for Neurodevelopmental, Neurology and Psychiatric Disorders, United Graduate School of Child Development, Osaka University, 5. Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry)

Keywords:Alzheimer’s disease, cerebral amyloid angiopathy, soluble high-molecular-weight Amyloid β, meninges