[2P] A. Neural Excitability, Synapses, and Glia: Cellular Mechanisms

[2P-084] Usability of human immortalized cell-based blood-brain barrier spheroid model for evaluation of macromolecular drug permeability via receptor-mediated transcytosis

*Hanae Morio¹, Keita Kitamura^1,2, Ayaka Okamoto¹, Ryo Ito³, Yoshiyuki Yamaura⁴, Takafumi Komori⁵, Tomomi Furihata¹ (1. Lab. Clin. Pharm. & Exp. Therap., Sch. Pharmacy., Tokyo Univ. Pharm. & Life Sci., 2. Lab. DDS Design & Drug Dispos., Grad. Sch. Pharm. Sci., Chiba Univ., 3. Res. Ctr. Neurol., Ono Pharm. Co., Ltd., 4. Dept. Pharmacokinet. Res., Ono Pharm. Co., Ltd., 5. Dept. Drug Metab. & Pharmacokinet., Eisai Co. Ltd.)

Keywords:Blood-brain barrier, In vitro BBB model, Receptor-mediated transcytosis, Transferrin receptor