[2WD06a1] 若手道場　治療法開発

[2WD06a1-04] A novel structure of oligonucleotides administered intracerebroventricularly improves efficacy and alleviates acute toxicity in mice

*Su Su Lei Mon¹, Kotaro Yoshioka¹, Chunyan Jia¹, Taiki Kuineda¹, Yutaro Asami¹, Kie Yoshida-Tanaka¹, Wenying Piao¹, Hiroya Kuwahara¹, Kazutaka Nishina¹, Tetsuya Nagata¹, Takanori Yokota¹ (1. 1Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences and Center for Brain Integration Research, Tokyo Medical and Dental University (TMDU), Tokyo, Japan)

キーワード：Central nervous system, Antisense oligonucleotides, Intracerebroventricular injection, Overhanging duplex oligonucleotides