[3O05m2] Synaptic Plasticity / Posttranslational Modulation and Proteolysis

[3O05m2-04] USP10 inhibits aberrant cytoplasmic aggregation of TDP-43 by promoting stress granule clearance

*Masahiko Takahashi¹, Hiroki Kitaura², Akiyoshi Kakita², Taichi Kakihana¹, Yoshinori Katsuragi¹, Osamu Onodera³, Masahiro Fujii¹ (1. Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2. Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan, 3. Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan)

Keywords:TAR DNA-binding protein 43 (TDP-43), Ubiquitin-specific protease 10 (USP10), Stress granule, Aggresome