[3P] E. Molecular and Neuronal Bases of Behavior 2

[3P-121] Exposure to GABA_A receptor antagonist picrotoxin in pregnant mice causes autism-like behaviors and aberrant gene expression in offspring

*Hiroko Kotajima^1,2, Hideo Hagihara³, Atsushi Sato^1,4, Yoko Hagino¹, Miho Tanaka⁵, Yoshihisa Katoh^1,6, Yasumasa Nishito^1,7, Yukio Takamatsu^1,7, Shigeo Uchino², Tsuyoshi Miyakawa³, Kazutaka Ikeda¹ (1. Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, 2. Department of Biosciences, School of Science and Engineering, Teikyo University, Tochigi, Japan, 3. Division of Systems Medical Science, Institute for Comprehensive Medical Science,Fujita Health University, Aichi, Japan, 4. Department of Pediatrics, The University of Tokyo Hospital, Tokyo, Japan, 5. Department of Neuropsychiatry, The University of Tokyo Hospital, Tokyo, Japan, 6. DeparGraduate School of Medicine, The University of Tokyo, Tokyo, Japan, 7. Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan)

Keywords:autism spectrum disorder, picrotoxin, GABAA receptor, social interaction