[4O05m1] Neurodegenerative Disorders 2

[4O05m1-02] ABCA1 deficiency in astrocytes triggers non-cell-autonomous optic neuropathy via neuroinflammation and excitotoxicity

*Youichi Shinozaki^1,2, Alex Leung³, Kazuhiko Namekata⁴, Nobuhiko Ohno^5,6, Eiji Shigetomi^2,1, Kenji Kashiwagi⁷, Takayuki Harada⁴, Shin-Ichi Ohnuma³, Schuichi Koizumi^1,2 (1. Dept Neuropharmacol, Grad Sch Med, Univ Yamanashi, Yamanashi, Japan, 2. GLIA Cent, Grad Sch Med, Univ Yamanashi, Yamanashi, Japan, 3. UCL Inst Ophthalmol, UCL, London, UK, 4. Vis Res Project, Tokyo Metr Inst Med, Tokyo, Japan, 5. Div Ultrastract Res, Natl Inst Physiol Sci, Aichi, Japan, 6. Div Anatomy, Jichi Med Univ, Tochigi, Japan, 7. Dept Ophthalmol, Interdisp Grad Sch Med, Univ Yamanashi, Yamanashi, Japan)

Keywords:Astrocytes, ABCA1, Glaucoma, Retinal ganglion cells