[4O05m2] Neurodegenerative Disorders 3

[4O05m2-04] Vulnerability in the hydrophobic region is crucial for species-specific aggregation of canine degenerative myelopathy-linked SOD1 E40K mutation.

*Kei Hashimoto¹, Seiji Watanabe¹, Okiru Komine¹, Akira Sobue¹, Hiroaki Kamishina², Yoshiaki Furukawa³, Koji Yamanaka¹ (1. Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, Japan, 2. Clinical Radiology, Joint Department of Veterinary Medicine, Gifu University, Gifu, Japan, 3. Mechanistic Chemistry for Biomolecules, Department chemistry, Keio University, Kanagawa, Japan)

Keywords:Canine degenerative myelopathy, Amyotrophic lateral sclerosis, Species-specific aggregation, hydrophobic region