Shoki Sato^1,2, Hisashi Uwatoko^1,2, Hiroaki Yaguchi², Moemi Yamada¹, Kazunori Sato¹, Atsushi Kawashima¹, Toshiyuki Fukazawa¹, Ichiro Yabe² (1.Sapporo Neurology Hospital, Japan, 2.Department of Neurology, Hokkaido University, Japan)

Kazumasa Yokoyama¹, Hirofumi Ochi², Toshiyuki Fukazawa³, Ryusuke Sato⁴, Haruki Makioka⁴, Yayoi Sato⁴, Aya Tsuchiya⁴, Yumiko Tani⁴, Ichino Chinen⁴, Takahi Yamamura⁵ (1.Tousei center for neurological diseases, Juntendo University School of Medicine, Department of Neurology, Japan, 2.Department of Intractable Disease and Aging Science, Ehime University Graduate School of Medicine, Japan, 3.Sapporo Neurology Hospital, Japan, 4.Biogen Japan Co., Ltd., Japan, 5.National Center of Neurology and Psychiatry, Department of Immunology, Japan)

Hisashi Uwatoko^1,2, Shoki Sato^1,2, Moemi Yamada², Kazunori Sato², Shinichi Shirai¹, Ikuko Iwata¹, Masaaki Matsuhima¹, Hiroaki Yaguchi¹, Atsushi Kawashima², Toshiyuki Fukazawa², Ichiro Yabe¹ (1.Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan, 2.Sapporo Neurology Hospital, Japan)

Ichiro Nakashima¹, Takashi Ohashi², Michihiro Kanda³, Yumiko Tani³, Kazumasa Yokoyama^4,5 (1.Tohoku Medical and Pharmaceutical University, Japan, 2.Yachiyo Medical Center, Tokyo Women and Medical University, Japan, 3.Biogen Japan Co., Ltd., Japan, 4.Juntendo University, Japan, 5.Tousei Neurological Center, Japan)

Ryusei Nagata, Yujiro Higuchi, Makoto Tokuda, Kentarou Oda, Akihiro Hashiguchi, Kumiko Michizono, Eiji Matsuura, Hiroshi Takashima (Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Japan)

Masahiro Mimori¹, Atsuko Katsumoto^1,2, Wakirou Satou^2,3, Youwei Lin^1,2,3, Reiko Saika^1,2, Tomoko Okamoto^1,2, Takashi Yamamura^2,3, Yuji Takahashi¹ (1.Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Japan, 2.Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry, Japan, 3.Immunology Department, Institute of Neuroscience, National Center Hospital, National Center of Neurology and Psychiatry, Japan)