[S-07] Symposium 07

[S-07-3] LRRK2, alpha-synuclein and lysosomal dysfunction in Parkinson's disease

Takeshi Iwatsubo, Tomoki Kuwahara (Department of Neuropathology, The University of Tokyo, Japan)

Takeshi Iwatsubo is a Professor of Neuropathology at the School of Medicine, The University of Tokyo, with a joint appointment as the Director of the National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan). Iwatsubo has contributed to the studies of Alzheimer’s and Parkinson’s disease, using multidisciplinary approaches. He demonstrated that Abeta42 is the initially deposited species in senile plaque amyloid, elucidated the process of gamma-secretase complex formation and identified phoshorylated alpha-synuclein as a component of Lewy bodies. Iwatsubo has been the PI of the Japanese AD Neuroimaging Initiative (J-ADNI), and PI of the Japanese Trial Ready Cohort for Prevention of Alzheimer’s Disease (J-TRC), aiming at developing disease-modifying therapies against Alzheimer’s Disease. He was awarded the MetLife Foundation 2008 Award for Medical Research and 2012 Potamkin Prize for Research in Pick’s, Alzheimer’s disease and related diseases.