*Io Horikawa¹, Hirotaka Nagai¹, Masayuki Taniguchi¹, Guowei Chen¹, Masakazu Shinohara^2,3, Tomohide Suzuki⁴, Shinichi Ishii⁴, Yoshio Katayama⁴, Shiho Kitaoka⁵, Tomoyuki Furuyashiki¹ (1. Division of Pharmacology, Graduate School of Medicine, Kobe University, Kobe, Japan, 2. Division of Molecular Epidemiology, Graduate School of Medicine, Kobe University, Kobe, Japan, 3. The Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, Japan, 4. Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 5. Department of Pharmacology, School of Medicine, Hyogo Medical University, Nishinomiya, Japan)