*Akira Sobue^1,2, Okiru Komine¹, Fumito Endo¹, Yuko Saito³, Shigeo Murayama^3,4, Takashi Saito^1,5, Takaomi Saido⁶, Koji Yamanaka¹ (1. Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, 2. Medical Interactive Research and Academia Industry Collaboration Center, Research Institute of Environmental Medicine, Nagoya University, 3. Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 4. Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development, Osaka University, 5. Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, 6. Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science)

*Tomoharu Kuboyama¹, Hikari Okamoto¹, Ami Idemoto¹, Chihiro Tohda² (1. Faculty of Pharmacy, Daiichi Univ of Pharmacy, Fukuoka, Japan, 2. Inst of Natural Medicine, Univ of Toyama, Toyama, Japan)

*Hiroko Yagihara¹, Toshihide Takeuchi², Yuko Saito³, Eiko N. Minakawa¹, kazuhiko seki¹ (1. Department of Neurophysiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan., 2. Life Science Research Institute, Kindai University, Osaka-Sayama, Osaka, Japan, 3. Department of Neuropathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-Ku, Tokyo, Japan)

*YANG SUN¹, Yuan Gao¹, Sadequl Islam¹, Tomohisa Nakamura¹, Taisuke Tomita³, Makoto Michikawa² (1. Graduate School of Medical Sciences, Nagoya City University, Nagoya, 2. School of Life Dentistry at Niigata, The Nippon Dental University, Niigata, Japan., 3. Faculty of Pharmaceutical Sciences, University of Tokyo, )

*Hideko Hashimoto¹, Iki Sonn¹, Rei Murakami¹, Hirotaka Watanabe¹, Hideyuki Okano¹ (1. Keio University School of Medicine, Tokyo, Japan)

*Taiyo Sawashige¹, Ikunori Ikesue¹, Noriko Isoo¹, Hironori Takagi¹, Takamasa Yoshida¹, Naoyuki Iso-o², Yukiko Hori³, Taisuke Tomita³, Toshihiro Hayashi¹ (1. Department of Physiology, Teikyo University School of Medicine, 2. Department of Internal Medicine, Teikyo University Mizonokuchi Hospital, 3. Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo)

*Eiko N Minakawa¹, Nanami Kohri², Terumi Nakatani¹, Jun Ogura¹, Shoichi Watanuki³, Kayoko Ikegami², Akiyo Kawanobe¹, Yasuko Nakamura¹, Akito Kosugi¹, Hiroko Yagihara¹, Siqin Gaowa², Toshihide Takeuchi⁴, Yuko Saito⁵, Miho Shidahara³, Koichi Kato¹, Ikuo Tomioka², Kazuhiko Seki¹ (1. Natl Inst Neurosci, Natl Ctr Neurol Psychiatr, Tokyo, Japan, 2. Faculty of Agriculture, Shinshu University, Nagano, Japan, 3. Grad Sch Engineering, Tohoku University, Miyagi, Japan, 4. Life Science Res Inst, Kindai University, Osaka, Japan, 5. Tokyo Metropol Inst Geriatr Gerontol, Tokyo, Japan)

*Takahiro Ishimoto¹, Reiya Yamashita¹, Yusuke Matsuo¹, Yusuke Masuo¹, Hiroki Sasaguri², Takashi Saito², Takaomi Saido², Yukio Kato¹ (1. Fac Pharm, Kanazawa Univ, Kanazawa, Japan, 2. Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Saitama, Japan)

*Tomoya Uchida¹, Naoki Kato¹, Shigeo Sakuragi¹, Akito Hattori¹, Yoshiyuki Soeda², Hideaki Yoshimura³, Akihiko Takashima², Hiroko Bannai¹ (1. Waseda University, School of Advanced Science and Engineering, 2. Gakushuin University, Faculty of Science, 3. The University of Tokyo, School of Science)