*Ritsuko Inoue¹, Shuichi Yanai², Hiroshi Nishimune^1,3 (1. Lab of Neurobiology of Aging, Tokyo Met Inst for Geriatrics and Gerontology, Tokyo, Japan, 2. Lab of Memory Neuroscience, Tokyo Met Inst for Geriatrics and Gerontology, Tokyo, Japan, 3. Dep of Applied Biological Science, Tokyo Univ of Agriculture and Technology, Tokyo, Japan)