[1P] 69 Alzheimer's Disease and Dementia

[1P-312] Nicotinic acetylcholine receptor activation induces BACE1 transcription via the phosphorylation and stabilization of nuclear SP1

*Masaki Nakano¹, Yachiyo Mitsuishi¹, Masaki Nishimura^1,2 (1. Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga, Japan, 2. Department of Neurology, Yoka Municipal Hospital, Hyogo, Japan)

Keywords:Alzheimer's disease, BACE1, Amyloid-β, Nicotinic acetylcholine receptor