[2P] 82 Molecular, Biochemical and Genetic Techniques

[2P-387] Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration

*Yoshio Iguchi¹, Ryoji Fukabori¹, Shigeki Kato¹, Kazumi Takahashi¹, Satoshi Eifuku¹, Yuko Maejima¹, Kenju Shimomura¹, Hiroshi Mizuma^2,3, Aya Mawatari², Hisashi Doi^2,4, Yilong Cui², Hirotaka Onoe⁵, Keigo Hikishima⁶, Makoto Osanai⁷, Takuma Nishijo^8,9, Toshihiko Momiyama⁸, Richard Benton¹⁰, Kazuto Kobayashi¹ (1. Fukushima Medical University School of Medicine , Fukushima, Japan, 2. RIKEN Center for Biosystems Dynamics Research, Kobe, Japan, 3. Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan, 4. Organization for Research Promotion, Osaka Metropolitan University, Sakai, Japan, 5. Kyoto University Graduate School of Medicine, Kyoto, Japan, 6. Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan, 7. Osaka University Graduate School of Medicine, Osaka, Japan, 8. Jikei University School of Medicine, 9. Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan, 10. Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland)

Keywords:Ionotropic Receptors, IR84a/IR8a complex, Pro-drug system, Chemogenetics