[2P] 13 Posttranslational Modulation and Proteolysis

[2P-408] Impaired proteolytic capacity in lysosomes leads to perturbation of development in neurons accompanied by accumulation of aggregated proteins

*Yinping Zhou¹, Yuuki Fujiwara¹, Mai Shirazaki², Xiaoye Tian¹, Taiichi Katayama¹ (1. Department of Child Development and Molecular Brain Science, United Graduate School of Child Development, Osaka University, Osaka, Japan, 2. Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan)

Keywords:lysosome, neurodevelopment, homeostasis, protein degradation