TBK1 activates immunoproteasome via IFNβ and suppresses accumulation of aggregation-prone monomeric TDP-43 and its phosphorylated form

Shohei Sakai

Presentation information

Training School for Next Generation Scientists

[2TS12a] DC, Disease 2

Thu. Jul 25, 2024 4:00 PM - 6:00 PM Room 12 (410)

Senior Discussant: Tadafumi Hashimoto (Department of Degenerative Neurological Diseases, National Center of Neurology and Psychiatry), Chihiro Tohda (Institute of natural Medicine, University of Toyama)
Young Chair: Ayaka Tatsumoto (Doshisha University)

[2TS12a-02] TBK1 activates immunoproteasome via IFNβ and suppresses accumulation of aggregation-prone monomeric TDP-43 and its phosphorylated form

*Shohei Sakai¹, Okiru Komine¹, Seiji Watanabe¹, Kotaro Oiwa^1,2, Koji Yamanaka¹ (1. Dept of Neurosci and Pathobiol, RIEM, Nagoya Univ, Aichi, Japan, 2. Dept of Neurol, Nagoya Univ, Aichi, Japan)

Keywords:amyotrophic lateral sclerosis (ALS), TDP-43, TBK1, IFNβ

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Presentation information

[2TS12a] DC, Disease 2

[2TS12a-02] TBK1 activates immunoproteasome via IFNβ and suppresses accumulation of aggregation-prone monomeric TDP-43 and its phosphorylated form

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