eIF5 stimulates RAN translation from the CUG codon of aberrantly elongated GGGGCC repeat sequence in <em>C9orf72</em> gene.

Shiho GOTOH

Presentation information

Training School for Next Generation Scientists

[2TS12m] DC, Disease 1

Thu. Jul 25, 2024 8:45 AM - 10:45 AM Room 12 (410)

Senior Discussant: Koh-ichi Nagata (Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center), Yuki Fujita (Graduate School of Medical Research, Shimane University)
Young Chair: Wakana Harigai (Osaka University)

[2TS12m-04] eIF5 stimulates RAN translation from the CUG codon of aberrantly elongated GGGGCC repeat sequence in C9orf72 gene.

*Shiho GOTOH¹, Kohji Mori¹, Yuzo Fujino ^2,3, Yuya Kawabe¹, Tomoko Yamashita ¹, Tsubasa Omi ¹, Kenichi Nagata⁴, Shinji Tagami¹, Yoshitaka Nagai², Manabu Ikeda¹ (1. Psychiatry, Grad Sch Med, Osaka Univ, Suita, Japan , 2. Neurology, Kindai Univ Faculty of Med, Osaka-Sayama, Japan , 3. Neurology, Kyoto Prefectural Univ Med, Kyoto, Japan , 4. Precision Medicine for Dementia, Grad Sch Med, Osaka Univ, Suita, Japan )

Keywords:RAN translation, C9orf72, eIF, FTLD

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