Concurrent loss of MUTYH and OGG1 in <em>App</em><sup>NL-G-F/NL-G-F</sup> knock-in mice leads to exacerbation of brain microgliosis and impaired response to the surrounding environment.

Yuri Mizuno

[3P-208] Concurrent loss of MUTYH and OGG1 in App^{NL-G-F/NL-G-F} knock-in mice leads to exacerbation of brain microgliosis and impaired response to the surrounding environment.

*Yuri Mizuno^1,2, Daisuke Tsuchimoto¹, Yoriko Akimoto¹, Yusaku Nakabeppu¹ (1. Div Neurofunctional Genomics, Dept Immunobiol and Neurosci, Med Inst Bioreg, Kyushu Univ, Fukuoka, Japan, 2. Dept of Neuro, Int Univ of Health and Welfare, Narita Hosp,Narita, Japan)

Keywords:MUTYH, OGG1, APP KNOCK-IN MICE, MICROGLIOSIS

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Presentation information

[3P] 54 Attention

[3P-208] Concurrent loss of MUTYH and OGG1 in App^{NL-G-F/NL-G-F} knock-in mice leads to exacerbation of brain microgliosis and impaired response to the surrounding environment.

Presentation information

[3P] 54 Attention

[3P-208] Concurrent loss of MUTYH and OGG1 in AppNL-G-F/NL-G-F knock-in mice leads to exacerbation of brain microgliosis and impaired response to the surrounding environment.

[3P-208] Concurrent loss of MUTYH and OGG1 in App^{NL-G-F/NL-G-F} knock-in mice leads to exacerbation of brain microgliosis and impaired response to the surrounding environment.