[3P] 69 Alzheimer's Disease and Dementia

[3P-298] Elucidation of the effect of peripheral immune environment on the disease-associated microglia induction in Alzheimer’s disease model mice

*Okiru Komine¹, Akira Sobue¹, Yuichiro Hara², Tomohiro Akashi^3,4, Shimada Mayuko², Kunihiko Hinohara^3,5,6, Tomoo Ogi², Takashi Saito^1,7, Takaomi Saido⁸, Koji Yamanaka¹ (1. Dept Neurosci & Pathobiol, Res Inst of Env Med, Nagoya Univ, 2. Dept Genetics, Res Inst of Env Med, Nagoya Univ, 3. Cent for 5D Cell Dynam, Nagoya Univ, 4. Cent for Neurol Dis & Cancer, Nagoya Univ Grad Sch of Med, 5. Dept of Immunl, Nagoya Univ Grad Sch of Med, 6. Inst for Adv Res, Nagoya Univ, 7. Dept of Neurocogn Sci, Inst of Brain Sci, Nagoya City Univ Grad Sch of Med Sci, 8. Lab for Proteol Neurosci, RIKEN Cent for Brain Sci)

Keywords:Alzheimer's disease, Disease-associated microglia, Peripheral immune system