[3P] 70 Neurodegenerative Disorders

[3P-336] Oligonucleotides-based approaches for modulating FUS phase separation in ALS/FTLD intervention

*Mohammad Moniruzzaman¹, Yusuke Fujioka ¹, Akihide Takeuchi ², Akio Masuda ³, Masahiro Neya ⁴, Yohei Okada ⁵, Shinsuke Ishigaki ¹ (1. Molecular Neuroscience Research Center, Shiga Univ of Medi Sci, 2. Dept of Developmental Biology and Functional Genomics, Ehime Univ Grad Sch of Med , 3. Center for Neurological Diseases and Cancer, Nagoya Univ Grad Sch of Med , 4. KNC Laboratories Co., Ltd , 5. Institute for Medicine Science of Aging, Aichi Med Univ )

Keywords:ALS, Fused in Sarcoma (FUS), Liquid liquid phase separation (LLPS), Oligonucleotide therapeutics