[4O08m] Human transcriptomics in psychiatric disorders

[4O08m-04] Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses

*Shinji Sakamoto^1,2, Xiaolei Zhu², Ishii Chiharu³, Matthew D Smith⁴, Ito Koki^5,2, Mizuho Obayashi², Lisa Unger⁶, Yuto Hasegawa², Shunya Kurokawa⁷, Taishiro Kishimoto^7,8, Hui Li^9,10, Shinya Hatano¹¹, Jeff Wang⁹, Yasunobu Yoshikai¹¹, Shin-ichi Kano¹², Shinji Fukuda^3,13,14,15, Kenji Sanada¹⁶, Peter A Calabresi^4,17, Atsushi Kamiya² (1. Dept Neuropsychiatry, Okayama Univ Hosp, Okayama, Japan, 2. Dept Psychiatry and Behavioral Sciences, Johns Hopkins Univ Sch Med, Baltimore, USA, 3. Inst Advanced Biosciences, Keio Univ, Tokyo, Japan, 4. Dept Neurology, Johns Hopkins Univ Sch Med, Baltimore, USA, 5. Dept Psychiatry, Hokkaido Univ Grad Sch Med, Hokkaido, Japan, 6. Inst Neuroimmunology and Multiple Sclerosis, University Medical Centre Hamburg–Eppendorf, Hamburg, Germany, 7. Dept Neuropsychiatry, Keio Univ Sch Med, Tokyo, Japan, 8. Hills Joint Research Laboratory for Future Preventive Medicine and Wellness, Keio Univ Sch Med, Tokyo, Japan, 9. Dept Mechanical Engineering and Biomedical Engineering, Johns Hopkins Univ, Baltimore, USA, 10. Sch Electrical, Computer and Biomedical Engineering, Southern Illinois Univ, Carbondale, USA, 11. Med Inst Bioregulation, Kyushu Univ, Fukuoka, Japan, 12. Dept Psychiatry and Behavioral Neurobiology, Univ Alabama at Birmingham Heersink Sch Med, Birmingham, USA, 13. Gut Environmental Design Group, Kanagawa Inst Industrial Science and Technology, Kawasaki, Japan. , 14. Transborder Medical Research Center, Univ Tsukuba, Tsukuba, Japan, 15. Lab Regenerative Microbiology, Grad Sch Med, Juntendo Univ, Tokyo, Japan, 16. Dept Psychiatry, Sch Med, Showa Univ, Tokyo, Japan, 17. Dept Neuroscience, Johns Hopkins Univ Sch Med, Baltimore, USA)

Keywords:Depression, Gut-Brain Axis, γδ T cells, Dectin-1