[4S05m] New frontiers of ALS/FTD research by young scientists

[4S05m-02] TDP-43-induced antero- and retrograde degeneration and propagation in the corticospinal circuits in mouse ALS models

*Shintaro Tsuboguchi¹, Yuka Nakamura², Tomohiko Ishihara³, Taisuke Kato⁴, Tokiharu Sato², Akihide Koyama⁵, Hideki Mori¹, Yuka Koike⁴, Osamu Onodera^1,4, Masaki Ueno² (1. Dept of Neurology, Brain Research Institute, Niigata Univ, Niigata, Japan, 2. Dept of System Pathology for Neurological Disorders, Brain Research Institute, Niigata Univ, Niigata, Japan, 3. Advanced Treatment of Neurological Diseases BranchBrain Research Institute, Niigata Univ, Niigata, Japan, 4. Dept of Molecular Neuroscience, Brain Research Institute, Niigata Univ, Niigata, Japan, 5. Division of Legal Medicine, Graduate School of Medicine and Dental Sciences, Niigata Univ, Niigata, Japan)

Keywords:TDP-43, spreading/propagation, AAV, mouse model