[HT-08] Hot Topics 08「New insights into ALS: genes, proteins, and pathways」

Sat. Jun 1, 2024 9:45 AM - 11:45 AM Room1 (Hall C, C Block, 4F, TIF)

Chair(s): Osmau Onodera (BRI, Niigata University, Japan), Koji Yamanaka (Nagoya University, RIEM, Japan)

+Add all to schedule

[HT-08-1] Mislocalization or Aggregation ? Dissecting the structural roles of ALS-linked misfolded proteins

Makoto Urushitani (Department of Neurology, Shiga University of Medical Science, Japan)

[HT-08-2] The role of RGMa in ALS progression through actin barrier collapse

Tatsusada Okuno (Department of Neurology, Osaka University Graduate School of Medicine, Osaka University, Japan)

[HT-08-3] Deciphering the pathophysiology of ALS focusing on the physiological multimerization of TDP-43

Kotaro Oiwa^1,2, Koji Yamanaka¹ (1.Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Japan, 2.Department of Neurology, Nagoya University, Japan)

[HT-08-4] TDP-43 regulates cryptic splicing of UNC13A, a key risk gene for ALS/FTD

Yuka Koike (Department of Molecular Neuroscience, Japan)

[HT-08-5] Targeting FUS Phase Separation in ALS: Therapeutic Approaches Using Oligonucleotides

Shinsuke Ishigaki (Molecular Neuroscience Research Center, Shiga University of Medical Science, Japan)

[HT-08-6] The new causative gene for ALS and myopathy

Hideshi Kawakami¹, Kodai Kume¹, Takashi Kurashige², Keiko Muguruma³ (1.Department of Molecular Epidemiology RIRBM Hiroshima University, Japan, 2.Department of Neurology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Japan, 3.Department of iPS Cell Applied Medicine, Graduate School of Medicine, Kansai Medical University, Japan)