Danno Daisuke¹, Shiho Suzuki², Tsubasa Takizawa³, Ryotaro Ishii⁴, Masayuki Hamakawa⁵, Yoshinori Tanizawa⁶, Minako Sato⁶, Satoshi Osaga⁶, Mika Komori⁶ (1.Tominaga Hospital, Osaka, Japan, 2.Dokkyo Medical University, Mibu, Japan, 3.Keio University School of Medicine, Tokyo, Japan, 4.Kyoto Prefectural University of Medicine, Kyoto, Japan, 5.Social Survey Research Information Co., Ltd, Tokyo, Japan, 6.Eli Lilly Japan K.K., Kobe, Japan)

Masahiko Hara^1,2, Yuichiro Murakawa², Keito Shinmoto² (1.Centre for Community-Based Healthcare Research and Education, Shimane University Faculty of Medicine, Japan, 2.Department of Neurology and Clinical Rehabilitation, mediVR Rehabilitation Center, Japan)

Hiroya Naruse^1,2, Hiroyuki Ishiura^1,3, Kayoko Esaki⁴, Jun Mitsui^1,2, Wataru Satake¹, Yuka Machino⁵, Yasumasa Kokubo⁶, Hirotoshi Hamaguchi⁷, Takeo Yoshikawa⁸, Shoji Tsuji⁹, Tatsushi Toda¹ (1.Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan, 2.Department of Precision Medicine Neurology, Graduate School of Medicine, The University of Tokyo, Japan, 3.Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan, 4.Department of Biotechnology and Life Sciences, Faculty of Biotechnology and Life Sciences, Sojo University, Japan, 5.Department of Neurology, National Hospital Organization Mie National Hospital, Japan, 6.Kii ALS/PDC Research Center, Graduate School of Regional Innovation Studies, Mie University, Japan, 7.Department of Neurology, Kita-Harima Medical Center, Japan, 8.Laboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Japan, 9.Institute of Medical Genomics, International University of Health and Welfare, Japan)

Tatsuhiko Sano^1,2, Tetsuya Nagata^1,2,3, Satoe Ebihara^1,2, Kie Yoshida-Tanaka^1,2, Ayako Nakamura^1,2, Asuka Sasaki^1,2, Aki Shimozawa⁵, Hideki Mochizuki⁴, Toshiki Uchihara^1,2, Masato Hasegawa⁵, Takanori Yokota^1,2,3 (1.Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan, 2.Center for Brain Integration Research, Tokyo Medical and Dental University, Japan, 3.NucleoTIDE and PepTIDE Drug Discovery Center, Tokyo Medical and Dental University, Japan, 4.Department of Neurology, Osaka University Graduate School of Medicine, Japan, 5.Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Japan)

Kazunori Toyoda¹, Yasuyuki Iguchi², Ichiro Nakahara³, Hirofumi Tomita⁴, Teruyuki Hirano⁵, Masahiro Yasaka⁶, Erika Pouliot⁷, Franco Noreli⁷, Kazuhiro Hidaka⁸, Ken Okumura⁹ (1.Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan, 2.Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan, 3.Department of Neurosurgery, Fujita Health University Bantane Hospital, Nagoya, Japan, 4.Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan, 5.Department of Stroke and Cerebrovascular Medicine, Kyorin University School of Medicine, Tokyo, Japan, 6.Department of Cerebrovascular Medicine, Fukuoka Neurosurgical Hospital, Fukuoka, Japan, 7.Cardiac Rhythm Management, Clinical Department, Medtronic Inc., Minneapolis, USA, 8.Japan Clinical and Medical Affairs, Medtronic Japan Co., Ltd., Tokyo, Japan, 9.Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto, Japan)

Hideki Shimazu^1,4, Shinichi Matsumoto², Hidetaka Koizumi³, Satoshi Goto^5,6, Masatoshi Koga⁵, Ryo Itabashi⁶, Yusuke Yakushiji⁷, on behalf of the ACUTE-PRAS Investigators (1.Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Japan, 2.Department of Neurology, Osaka Neurological Institute, Japan, 3.Department of Neurology, Kyoto Prefectural Rehabilitation Hospital for the Disabled, Japan, 4.Department of Neurology, Itsuki Hospital, Japan, 5.Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University, Japan, 6.Center for Drug Discovery and Development Sciences, Research Organization of Science and Technology, Ritsumeikan University, Japan, 7.Department of Neurology, Kansai Medical University, Japan)

Shigeru Fujimoto¹, Kazumi Kimura², Yasuyuki Iguchi³, Hiroshi Yamagami⁴ (1.Department of Medicine, Division of Neurology, Jichi Medical University, Japan, 2.Department of Neurology, Graduate School of Medicine, Nippon Medical School, Japan, 3.Department of Neurology, The Jikei University School of Medicine, Japan, 4.Department of Stroke Neurology, National Hospital Organization Osaka National Hospital, Japan, 5.Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Japan, 6.Stroke Center, Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Japan, 7.Department of Neurology, Kansai Medical University, Japan)

Gaurav Chopra^1,3, Priya Prakash¹, Palak Manchanda¹, Evi Paouri², Kanchan Bisht¹, Kaushik Sharma¹, Ahad Hossain¹, Prageeth R. Wijewardhane¹, Caitlin E. Randolph¹, Alexis Crockett², Nadia Gasmi², Jonathan Fine¹, Victoria Wendt¹, Krupal P. Jethava¹, Matthew G. Clark¹, Sarah Stanko², Elizabeth A. Thayer¹, Anxhela Gjojdeshi², Ryann Davis¹, Dhruv Hardikar¹, Chi Zhang¹, Dimitrios Davalos² (1.Department of Chemistry, Purdue University, USA, 2.Department of Neurosciences, Cleveland Clinic, USA, 3.Purdue Institute for Integrative Neuroscience, Regenstrief Center for Healthcare Engineering, Purdue University, Purdue Institute for Drug Discovery, Purdue University, USA)

Saraswati Nashi¹, Tanushree Chawla¹, Dipti Baskar¹, Kiran Polavarapu², Seena Vengalil¹, Mainak Bardhan¹, Veeramani Preethish-Kumar¹, Ramya Sukrutha³, Gopikrishnan Unnikrishnan¹, Akshata Huddar¹, Hansashree Padmanabha¹, Ram Murthy Anjanappa³, Nandeesh Bevinahalli⁴, Vidya Nittur¹, Manoj Rajanna¹, Gautham Arunachal Udupi³, Atchayaram Nalini¹ (1.Department of Neurology, Neuroscience Faculty Center, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, 560029, India, 2.Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Canada, 3.Department of Human Genetics, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, 560029, India, 4.Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, India)