Mari Shibukawa¹, Takehisa Hirayama¹, Harumi Morioka¹, Tatsuhiro Yokoyama¹, Hiroshi Tsuda¹, Kota Bokuda², Mieko Ogino³, Hiroyuki Takao⁴, Mitsuya Morita⁵, Yoshiaki Takahashi⁶, Ryoichi Nakamura⁷, Naoki Atsuta⁷, Koji Yamanaka⁸, Yuishin Izumi⁹, Makoto Urushitani¹⁰, Osamu Kano¹ (1.Department of Neurology, Toho University Faculty of Medicine, Japan, 2.Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan, 3.Department of Neurology, Office of Medical Education, International University of Health and Welfare, School of Medicine, Japan, 4.Department of Neurology, Jikei University School of Medicine, Japan, 5.Division of Neurology, Department of Internal Medicine, Jichi Medical University, Japan, 6.Yui Life Communication Laboratory, Japan, 7.Department of Neurology, Aichi Medical University School of Medicine, Japan, 8.Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Japan, 9.Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Japan, 10.Department of Neurology, Shiga University of Medical Science, Japan)

Yui Kamijo¹, Akiyo Hineno^2,3, Takashi Fujihara⁴, Masaomi Takizawa⁵, Yoshiki Sekijima^2,3, Akinori Nakamura^6,7 (1.Department of Neurology, NHO Shinshu Ueda Medical Center, Japan, 2.Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan, 3.Shinshu Medical Care Collaboration Center, Shinshu University Hospital, Japan, 4.Kissei Comtec Co. Ltd., Japan, 5.Central Corridor Communication 21, Japan, 6.Department of Clinical Research, NHO Matsumoto Medical Center, Japan, 7.Third Department of Medicine, Shinshu University School of Medicine, Japan)

Kazunari Onodera^1,2, Daisuke Shimojo^1,3, Yasuharu Ishihara³, Akinobu Ota^4,5, Fuyuki Miya⁶, Rashid Muhammad Irfanur¹, Takuji Ito¹, Rina Okada¹, Yoshitaka Hosokawa⁴, Manabu Doyu⁷, Gen Sobue⁸, Masahisa Katsuno², Hideyuki Okano³, Yohei Okada¹ (1.Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University, Japan, 2.Department of Neurology, Nagoya University Graduate School of Medicine, Japan, 3.Department of Physiology, Keio University School of Medicine, Japan, 4.Department of Biochemistry, Aichi Medical University School of Medicine, Japan, 5.Department of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Japan, 6.Center for Medical Genetics, Keio University School of Medicine, Japan, 7.Department of Neurology, Aichi Medical University School of Medicine, Japan, 8.Aichi Medical University, Japan)

Ayano Kondo¹, Madoka Iida¹, Shinichiro Yamada¹, Takahiro Kawase¹, Shota Komori¹, Yoshiyuki Kishimoto¹, Daisuke Ito¹, Atsushi Hashizume², Masahisa Katsuno¹ (1.Department of Neurology, Nagoya University Graduate School of Medicine, Japan, 2.Department of Clinical Research Education, Nagoya University Graduate School of Medicine, Japan)

Taihei Homma¹, Montes Jacqueline², Youn Bora³, Pasternak Amy⁴, Mercuri Eugenio⁵, Coratti Giorgia⁶, Chin Russell³, Berger Zdenek³, Johnson Nicole³, Paradis Angela D.³ (1.Biogen Japan Ltd., Japan, 2.Columbia University Irving Medical Center, USA, 3.Biogen, Inc., USA, 4.Boston Children's Hospital, Harvard Medical School, USA, 5.Department of Paediatric Neurology and Nemo Clinical Centre, Catholic University, Italy, 6.Catholic University, Italy)

Senri Ko¹, Ryo Yamasaki¹, Tasuku Okui², Wataru Shiraishi^1,3, Mitsuru Watanabe¹, Yu Hashimoto^1,4, Yuko Kobayakawa^1,5, Susumu Kusunoki^6,7, Jun-ichi Kira^8,9, Noriko Isobe¹ (1.Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan, 2.Medical Information Center, Kyushu University Hospital, Japan, 3.Department of Neurology, Kokura Memorial Hospital, Japan, 4.Department of Neurology, Kochi Medical School, Kochi University, Japan, 5.Center for Clinical and Translational Research, Kyushu University Hospital, Japan, 6.Department of Neurology, Kindai University Faculty of Medicine, Japan, 7.Japan Community Health care Organization Headquarters, Japan, 8.Translational Neuroscience Research Center, Graduate School of Medicine, and School of Pharmacy at Fukuoka, International University of Health and Welfare, Japan, 9.Department of Neurology, Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, Japan)