[Pe-071] English Poster Session 071「Neurogenetics, Gene therapy, and iPS cell 4」

Sat. Jun 1, 2024 1:15 PM - 2:35 PM Poster (Hall E, E Block, B2F, TIF)

Chair(s): Hiroyuki Morino (Department of Medical Genetics, Tokushima University Graduate School of Biomedical Sciences, Japan), Hirofumi Yamashita (Japanese Red Cross Wakayama Medical Center, Japan)

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[Pe-071-1] Alternatively spliced novel isoforms of SHSPB8 and its role in neurodegeneration

Naira Rashid (Jamia Hamdard, India)

[Pe-071-2] Identification of drug targets for Alzheimer's disease by integrating genetics and proteomes

Ya-nan Ou¹, Lan Tan¹, Jin-tai Yu² (1.Qingdao Municipal hospital, Qingdao University, China, 2.Huashan hospital, Fudan University, China)

[Pe-071-3] Nanobubble-Mediated Carrier-Free mRNA Delivery into the CNS Using Low-Frequency Ultrasound

Hiroshi Kida, Takayuki Koga, Yutaro Yamasaki, Hitomi Endo, Feril Loreto B., Katsuro Tachibana (Department of Anatomy, School of Medicine, Fukuoka University, Japan)

[Pe-071-4] siRNA-mediated ATN1 mRNA knockdown markedly improves the phenotype of DRPLA model mice

Mitsuto Sato^1,2, Mitsunori Yamada², Shin Shimada³, Takahiro Yoshizawa³, Toshiya Sato⁴, Cantley William⁵, Shoji Tsuji^6,7, Yoshiki Sekijima^1,8 (1.Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan, 2.Department of Brain Disease Research, Shinshu University School of Medicine, Japan, 3.Research Center for Advanced Science and Technology, Shinshu University, Japan, 4.Department of Laboratory Animal Science, Kitasato University School of Medicine, Japan, 5.Alnylam Pharmaceuticals, USA, 6.Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan, 7.Institute of Medical Genomics, International University of Health and Welfare, Japan, 8.Institute for Biomedical Sciences, Shinshu University, Japan)

[Pe-071-5] Gene therapy for amyotrophic lateral sclerosis by microRNA with homing peptides to microglia in mice

Tomoya Terashima, Kazuki Mera, Nguyen Ngoc Bach, Shunya Kaneko, Ryutaro Nakamura, Ryota Tamura, Takahito Tsukamoto, Hiroyuki Yabata, Shuhei Kobashi, Yoshitaka Tamaki, Nobuhiro Ogawa, Akihiro Kitamura, Isamu Yamakawa, Makoto Urushitani (Department of Neurology, Shiga University of Medical Science, Japan)

[Pe-071-6] Clinical genetic approaches for at risk family members with hereditary transthyretin amyloidosis

Katsuya Nakamura^1,2, Tsuneaki Yoshinaga¹, Akiko Sakyu², Akira Matsushima¹, Yuka Yonehara², Tomomi Kojima², Emiko Kise², Tomoki Kosho^2,3, Yoshiki Sekijima¹ (1.Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan, 2.Center for Medical Genetics, Shinshu University Hospital, Japan, 3.Department of Medical Genetics, Shinshu University School of Medicine, Japan)

[Pe-071-7] Establishment of an axonopathy iPSC cohort for disease modeling and drug discovery

Takeshi Niki^1,2, Keiko Imamura^1,2,3, Mika Suga^1,2, Ryo Ohara⁴, Fukiko Morii⁴, Masanori Nakagawa⁴, Mitsuya Morita⁵, Takayasu Mishima⁶, Yoshio Tsuboi⁶, Yuishin Izumi⁷, Haruhisa Inoue^1,2,3 (1.iPSC-based Drug Discovery and Development Team, RIKEN BioResource Research Center (BRC), Japan, 2.Center for iPS Cells for Research and Application (CiRA), Kyoto University, Japan, 3.Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Japan, 4.Department of Neurology, Kyoto Prefectural University of Medicine, Japan, 5.Division of Neurology, Department of Internal Medicine, Jichi Medical University Hospital, Japan, 6.Department of Neurology, Fukuoka University School of Medicine, Japan, 7.Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Japan)