[LB] Late Breaking Symposium

[LB-5] Effects of local reduction of endogenous α-synuclein using antisense oligonucleotides on the fibril-induced propagation of pathology through the neural network in wild-type mice

Tatsuhiko Sano^1,2, Tetsuya Nagata^1,2,3, Satoe Ebihara^1,2, Kie Yoshida-Tanaka^1,2, Ayako Nakamura^1,2, Asuka Sasaki^1,2, Aki Shimozawa⁵, Hideki Mochizuki⁴, Toshiki Uchihara^1,2, Masato Hasegawa⁵, Takanori Yokota^1,2,3 (1.Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan, 2.Center for Brain Integration Research, Tokyo Medical and Dental University, Japan, 3.NucleoTIDE and PepTIDE Drug Discovery Center, Tokyo Medical and Dental University, Japan, 4.Department of Neurology, Osaka University Graduate School of Medicine, Japan, 5.Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Japan)