[NFS-02] Neuroscience Frontier Symposium 02「Progress in research on Parkinson's pathogenesis」

[NFS-02-4] Autophagy as a guardian against ageing and age-related neurodegeneration

Viktor I. Korolchuk (Newcastle University, Biosciences Institute, Ageing Research)

Scientific background:
• Associate Professor, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, UK, since 2017
• Lecturer, Institute for Cell and Molecular Biosciences, Newcastle University, UK, 2011- 2017
• Postdoctoral Fellow, University of Cambridge, UK, 2003-2011
• PhD in Biochemistry, Institute of Biochemistry, Kyiv, National Academy of Sciences, Ukraine, 2000
• Research interests: autophagy and its regulation by mTOR signalling in the context of cellular and organismal ageing; role of autophagy in the maintenance of protein, DNA and organelle homeostasis; autophagy as a mechanism of oxidative stress response.

Recent Publications:
Kelly G et al. Basal Mitophagy is Suppressed in Cellular Senescence and Mediates Senescence Phenotypes. Sneak Peek (preprint), doi:10.2139/ssrn.4137695.
Victorelli S et al. Sub-lethal apoptotic stress enables mtDNA release during senescence and drives the SASP. Nature. 2023.
Sun C et al. NAD Depletion mediates cytotoxicity in human neurons with autophagy deficiency. Cell Rep. 2023 Apr 20;42(5):112372.
Kataura T et al. NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy. EMBO J. 2022 Dec 14:e111372.
Kataura T et al. Autophagy promotes cell survival by maintaining NAD levels. Dev Cell. 2022 Nov 22, 57:21.