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Hock-Kean Liew^1,2,3, Hsin-yi Huang³, Wei-fen Hu¹, Chien-hui Lee⁴, Sheng-tzung Tsai^2,4,5, Shaik Ismail Mohammed Thangameeran⁵, Cheng-yoong Pang^2,3,5 (1.PhD Program in Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan, 2.Neuro-Medical Scientific Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, 3.Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, 4.Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, 5.Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan)