[3O10m-2] ALS/Tauopathy

[3O10m-2-03] Selective disruption of inhibitory synapses leading to neuronal hyperexcitability at an early stage of tau pathogenesis in a mouse model

*MASAFUMI SHIMOJO¹, Hiroyuki Takuwa¹, Yuhei Takado¹, Masaki Tokunaga¹, Satoshi Tsukamoto², Keiichiro Minatohara¹, Maiko Ono¹, Chie Seki¹, Jun Maeda¹, Takuya Urushihata¹, Takeharu Minamihisamatsu¹, Ichio Aoki³, Kazunori Kawamura⁴, ming-rong Zhang⁴, Tetsuya Suhara¹, Naruhiko Sahara¹, Makoto Higuchi¹ (1. Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 2. Laboratory Animal and Genome Sciences Section, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 3. Department of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 4. Department of Radiopharmaceuticals Development, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan)