[1P] Schizophrenia

[1P-129] Chemogenetic activation of prefrontal parvalbumin interneurons in combination with clinically comparable antipsychotic treatment restores working memory deficits in a mouse model of schizophrenia

〇Yosefu Arime¹, Yoshito Saitoh¹, Yasuo Uchida², Mikiko Ishikawa¹, Chikako Kamiyoshihara¹, Kazuki Fujii^3,4, Keizo Takao^3,4, Noriaki Ohkawa¹ (1.Division for Memory and Cognitive Function, Research Center for Advanced Medical Science, Dokkyo Medical University, Tochigi, Japan, 2.Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan, 3.Department of Behavioral Physiology, Faculty of Medicine, University of Toyama, Toyama, Japan, 4.Life Science Research Center, University of Toyama, Toyama, Japan)

Keywords:WORKING MEMORY, PRELIMBIC CORTEX, PARVALBUMIN, CHEMOGENETICS