[1P] Neural Circuit Manipulation

[1P-142] Development of a new chemogenetic neuronal activation system based on insect Ionotropic Receptors

〇Yoshio Iguchi¹, Ryoji Fukabori¹, Shigeki Kato¹, Kazumi Takahashi², Satoshi Eifuku², Akihiro Hazama³, Motokazu Uchigashima⁴, Masahiko Watanabe⁵, Hiroshi Mizuma⁶, Yilong Cui⁷, Hirotaka Onoe⁸, Keigo Hikishima⁹, Yasunobu Yasoshima¹⁰, Makoto Osanai¹¹, Ryo Inagaki¹², Kohji Fukunaga¹³, Takuma Nishijo¹⁴, Toshihiko Momiyama¹⁵, Richard Benton¹⁶, Kazuto Kobayashi¹ (1.Dept Mol Genet, Fukushima Med Univ, Fukushima, Japan, 2.Dept Systems Neurosci, Fukushima Med Univ, Fukushima, Japan, 3.Dept Cell Integr Physiol, Fukushima Med Univ, Fukushima, Japan, 4.Dept Cell Neuropathol, Brain Research Institute, Niigata Univ, Japan, 5.Dept Anatomy, Faculty of Medicine, Hokkaido Univ, Japan, 6.Lab Pathophysiological & Health Science, RIKEN BDR, Japan, 7.Lab Biofunction Dynamics Imaging, RIKEN BDR, Japan, 8.Human Brain Research Center, Kyoto Univ Grad Sch Med, Japan, 9.Medical Devices Research Group, AIST, Japan, 10.Div Behav Physiol, Grad Sch of Human Sci, Osaka Univ, Japan, 11.Dept Medical Physics & Engineering, Osaka Univ Grad Sch Med, Japan, 12.Tohoku Univ Grad Sch of Pharmaceutical Sci, Japan, 13.Dept Pharmacol, Grad Sch of Pharm Sci, Tohoku Univ, Japan, 14.Institute for Developmental Research, Aichi Developmental Disability Center, Japan, 15.Dept Pharmacol, Jikei Univ Sch Med, Japan, 16.Center for Integrative Genomics, Univ of Lausanne, Switzerland)

Keywords:chemogenetic tool, insect Ionotropic Receptor, IR84a/IR8a complex, phenylacetic acid