[4P] Neurodegenerative Disorders

[4P-384] A conformational feature of extracellular misfolded SOD1 with prion-like properties in the extracellular environment surrounding motor neuron-like cells

〇Eiichi Tokuda¹, Chika Takashima¹, Yasuhiro Kosuge¹, Masahisa Inoue², Shin-ichi Ono^1,3 (1.Sch Pharm, Nihon Univ, Chiba, Japan, 2.Fac Pharm Sci, Tokushima Bunri Univ, Tokushima, Japan, 3.Dep Neurol, Akiru Med Center, Tokyo, Japan)

Keywords:Amyotrophic lateral sclerosis, Extracellular environment, Prion-like transmissibility, Protein misfolding