Neural cell-specific SQSTM1 deficiency exacerbates disease symptoms in a SOD1<sup>H46R</sup>-expressing ALS mouse model by regulating the formation and distribution of ubiquitin-positive aggregates in motor neurons

Shun Mitsui, Asako Otomo, Kai Sato, Kento Shimakura, Tetsuro Ishii, Toru Yanagawa, Masashi Aoki, Shinji Hadano

[4P-390] Neural cell-specific SQSTM1 deficiency exacerbates disease symptoms in a SOD1^H46R-expressing ALS mouse model by regulating the formation and distribution of ubiquitin-positive aggregates in motor neurons

〇Shun Mitsui^1,2, Asako Otomo², Kai Sato², Kento Shimakura², Tetsuro Ishii³, Toru Yanagawa³, Masashi Aoki⁴, Shinji Hadano² (1.Dept Cell Mol Neuropath, Juntendo Univ Grad Sch Med, Tokyo, Japan, 2.Dept Mol Life Sci, Tokai Univ Sch Med, Kanagawa, Japan, 3.Facul Med, Univ of Tsukuba, Ibaraki, Japan, 4.Dept Neurol, Tohoku Univ Grade Sch Med, Sendai, Japan)

Keywords:ALS, SQSTM1, SOD1, Ubiquitin

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Presentation information

[4P] Neurodegenerative Disorders

[4P-390] Neural cell-specific SQSTM1 deficiency exacerbates disease symptoms in a SOD1^H46R-expressing ALS mouse model by regulating the formation and distribution of ubiquitin-positive aggregates in motor neurons

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Presentation information

[4P] Neurodegenerative Disorders

[4P-390] Neural cell-specific SQSTM1 deficiency exacerbates disease symptoms in a SOD1H46R-expressing ALS mouse model by regulating the formation and distribution of ubiquitin-positive aggregates in motor neurons

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[4P-390] Neural cell-specific SQSTM1 deficiency exacerbates disease symptoms in a SOD1^H46R-expressing ALS mouse model by regulating the formation and distribution of ubiquitin-positive aggregates in motor neurons